Prior to administration of SENTINEL SPECTRUM Chews, dogs should be tested for existing heartworm infections. Precautions: Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention (see EFFECTIVENESS). If it is suspected that any of the dose has been lost, redosing is recommended. Care should be taken that the dog consumes the complete dose, and treated animals should be observed a few minutes after administration to ensure that no part of the dose is lost or rejected. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. The chewables should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. SENTINEL SPECTRUM Chews may be offered to the dog by hand or added to a small amount of dog food. To ensure adequate absorption, always administer SENTINEL SPECTRUM Chews to dogs immediately after or in conjunction with a normal meal. Dosage Schedule Body WeightĪdminister the appropriate combination of chewables For heartworm prevention, give once monthly for at least 6 months after exposure to mosquitoes (see EFFECTIVENESS). Praziquantel is an isoquinolone anthelmintic with the chemical name 2-(Cyclohexylcarbonyl)-1,2,3,6,7,-11b-hexahydro-4H-pyrazinoisoquinolin-4-one.ĭosage and Administration: SENTINEL SPECTRUM Chews should be administerd orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, 4.55 mg/lb (10 mg/kg) lufenuron, and 2.28 mg/lb (5 mg/kg) praziquantel. Benzoylphenylurea compounds, including lufenuron, are classified as insect development inhibitors (IDIs).
Lufenuron is a benzoylphenylurea derivative with the following chemical composition: N-2,6-difluorobenzamide (C 17H 8CI 2F 8N 2O 3, MW 511.15). Milbemycin oxime is classified as a macrocyclic anthelmintic. Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A 4 (C 32H 45NO 7, MW 555.71) and 20% A 3 (C 31H 43NO 7, MW 541.68).
Each chewable flavored tablet is formulated to provide a minimum of 0.23 mg/pound (0.5mg/kg) of milbemycin oxime, 4.55 mg/pound (10mg/kg) of lufenuron, and 2.28 mg/pound (5mg/kg) of praziquantel. Description: SENTINEL ® SPECTRUM ® Chews are available in four strengths in color-coded packages for oral administration to dogs and puppies according to their weight.
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